PCDHA6 Rabbit Polyclonal Antibody (CAB4856)
- SKU:
- CAB4856
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- PCDHA6
- CNR2
- CNRN2
- CNRS2
- CRNR2
- PCDH-ALPHA6
- Research Area:
- Cell Biology
Description
Product Name: | PCDHA6 Rabbit Polyclonal Antibody |
SKU: | CAB4856 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human PCDHA6 (NP_061732.1). |
Sequence: | MVFT PEDR LGKQ CLLL PLLL LAAW KVGS GQLH YSVP EEAK HGTF VGRI AQDL GLEL AELV PRLF RMAS KDRE DLLE VNLQ NGIL FVNS RIDR EELC GRSA ECSI HLEV IVDR PLQV FHVD VEVR DIND NPPL FPVE EQRV LIYE SRLP DSVF PLEG ASDA DVGS NSIL TYKL SSSE YFGL DVKI NSDD NKQI GLLL KKSL DREE APAH NLFL TATD GGKP ELTG TVQL LV |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | CNR2; CNRN2; CNRS2; CRNR2; PCDH-ALPHA6; PCDHA6 |
Positive Sample: | Mouse skeletal muscle,Mouse liver,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Secreted, Single-pass type I membrane protein. |
Calculated MW: | 103kDa |
Observed MW: | 103kDa |
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
Purification Method: | Affinity purification |
Gene ID: | 56142 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |