The PCDHA3 Polyclonal Antibody (PAC011096) is a valuable tool for researchers studying PCDHA3, a member of the protocadherin alpha gene cluster involved in cell adhesion and neural development. This antibody, generated in rabbits, exhibits strong reactivity with human samples and has been validated for use in various applications, including Western blotting.PCDHA3 is known to play a crucial role in neuronal connectivity and synaptic plasticity, making it a key player in the development and function of the nervous system. Dysregulation of PCDHA3 has been implicated in various neurological disorders, making it a promising target for further research in neuroscience and neurodevelopmental studies.
By using the PCDHA3 Polyclonal Antibody, researchers can effectively detect and analyze PCDHA3 protein expression in different cell types, providing insights into its function and potential implications in neurobiology. This antibody is an essential tool for advancing our understanding of PCDHA3 and its role in neural development and disease pathogenesis.
PCDHA3: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 5q31Cellular Component: integral to plasma membraneBiological Process: cell adhesion; nervous system development
UniProt Protein Details:
NCBI Summary:
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]
