The PCDH8 Polyclonal Antibody (CAB14250) is a valuable tool for researchers studying PCDH8, a protein involved in cell adhesion and signaling pathways. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the PCDH8 protein, this antibody enables the detection and analysis of PCDH8 expression in various cell types.PCDH8, also known as protocadherin-8, is a member of the protocadherin family that plays a crucial role in cell-cell adhesion and communication in the nervous system. Dysregulation of PCDH8 has been implicated in various diseases, including cancer and neurological disorders.
Research into the function of PCDH8 is essential for gaining insight into its role in these conditions and developing potential therapeutic strategies targeting this protein.Overall, the PCDH8 Polyclonal Antibody is a reliable tool for researchers interested in investigating the function and expression of PCDH8 in a range of biological contexts, including cancer biology, neurobiology, and developmental biology. Its high specificity and sensitivity make it an ideal choice for studying the role of PCDH8 in health and disease.
Product Name:
PCDH8 Rabbit Polyclonal Antibody
SKU:
CAB14250
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 450-750 of human PCDH8 (NP_002581.2).
Cell junction, Cell membrane, Cell projection, Single-pass type I membrane protein, dendrite, postsynaptic cell membrane, presynaptic cell membrane, synapse.
Calculated MW:
113kDa
Observed MW:
113kDa
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes an integral membrane protein that is thought to function in cell adhesion in a CNS-specific manner. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons. Notable is the large first exon encoding the extracellular region, including 6 cadherin domains and a transmembrane region. Alternative splicing yields isoforms with unique cytoplasmic tails.
Purification Method:
Affinity purification
Gene ID:
5100
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PCDH8 Rabbit pAb (CAB14250) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
