The PCDH11Y/PCDH11X Antibody (PACO05447) is a polyclonal antibody designed for research involving the PCDH11Y and PCDH11X proteins. These cell surface molecules are members of the protocadherin family, which play important roles in cell-cell adhesion and communication. The antibody, generated in rabbits, is highly specific and reacts with human samples, making it a reliable tool for Western blot applications.The PCDH11Y/PCDH11X Antibody binds to the PCDH11Y and PCDH11X proteins, enabling researchers to detect and analyze these molecules in various cell types. This makes it ideal for studies in developmental biology, neurobiology, and cancer research.
Understanding the functions and interactions of PCDH11Y and PCDH11X is essential for unraveling their roles in cell signaling, neuronal development, and disease pathogenesis.Overall, the PCDH11Y/PCDH11X Antibody is a valuable tool for researchers interested in exploring the functions and mechanisms of action of PCDH11Y and PCDH11X in biological processes and disease states. Its specificity, reliability, and versatility make it a critical asset for studies aiming to uncover the molecular pathways regulated by these protocadherin proteins.
Antibody Name:
PCDH11Y/PCDH11X Antibody (PACO05447)
Antibody SKU:
PACO05447
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC, IF
Recommended Dilutions:
ELISA:1:20000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from the Internal region of human Protocadherin-11.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
PCDH11Y; PCDH11; PCDH22; PCDHY; Protocadherin-11 Y-linked; Protocadherin-11; Protocadherin on the Y chromosome; PCDH-Y; Protocadherin prostate cancer; Protocadherin-PC; Protocadherin-22; PCDH11X; KIAA1326; PCDH11; PCDHX; Protocadherin-11 X-
UniProt Protein Function:
PCDH11Y: Potential calcium-dependent cell-adhesion protein. A chromosomal aberration involving PCDH11Y is a cause of multiple congenital abnormalities, including severe bilateral vesicoureteral reflux (VUR) with ureterovesical junction defects. Translocation t(Y;3)(p11;p12) with ROBO2. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: Yp11.2
UniProt Protein Details:
NCBI Summary:
This gene belongs to the protocadherin family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing seven cadherin repeats, a transmembrane domain, and a cytoplasmic tail that differs from those of the classical cadherins. This gene is located on the Y chromosome in a block of X/Y homology and is very closely related to its paralog on the X chromosome. The protein is thought to play a role in cell-cell recognition during development of the central nervous system. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
