The PCDH11Y Polyclonal Antibody (PAC011094) is a valuable tool for researchers studying PCDH11Y, a cell adhesion molecule involved in neuronal development and function. This antibody, produced in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot applications. By binding to the PCDH11Y protein, this antibody enables the detection and analysis of PCDH11Y in various cell types, making it a useful tool for studies in neuroscience and neurodevelopmental disorders.PCDH11Y, a member of the protocadherin family, plays a crucial role in neuronal connectivity and synaptic plasticity, making it a key player in brain development and function.
Dysregulation of PCDH11Y has been linked to neurodevelopmental disorders such as autism spectrum disorders and intellectual disabilities. By understanding the function of PCDH11Y, researchers can gain insights into the mechanisms underlying these disorders and potentially develop targeted therapies to address them.Overall, the PCDH11Y Polyclonal Antibody is a valuable resource for scientists investigating the role of PCDH11Y in neuronal development, synaptic plasticity, and neurodevelopmental disorders. Its high reactivity and specificity make it a reliable tool for studying this important cell adhesion molecule in both basic research and clinical applications.
PCDH11Y: Potential calcium-dependent cell-adhesion protein. A chromosomal aberration involving PCDH11Y is a cause of multiple congenital abnormalities, including severe bilateral vesicoureteral reflux (VUR) with ureterovesical junction defects. Translocation t(Y;3)(p11;p12) with ROBO2. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: Yp11.2
UniProt Protein Details:
NCBI Summary:
This gene belongs to the protocadherin family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing seven cadherin repeats, a transmembrane domain, and a cytoplasmic tail that differs from those of the classical cadherins. This gene is located on the Y chromosome in a block of X/Y homology and is very closely related to its paralog on the X chromosome. The protein is thought to play a role in cell-cell recognition during development of the central nervous system. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
