The Protocadherin-1 Polyclonal Antibody (CAB10234) is a valuable tool for research involving Protocadherin-1, a cell adhesion protein involved in various physiological processes. This antibody, produced in rabbits, exhibits high reactivity towards human samples and has been validated for use in Western blot applications. By binding specifically to Protocadherin-1, this antibody allows for the detection and analysis of this protein in a variety of cell types, making it an excellent choice for studies in developmental biology and neuroscience.
Protocadherin-1 is known to play a crucial role in cell-cell adhesion, neuronal development, and synaptic function. It has been implicated in various neurological disorders, making it a promising target for research into conditions such as autism, schizophrenia, and Alzheimer's disease. Understanding the function of Protocadherin-1 is essential for elucidating its role in these disorders and potentially developing targeted therapies in the future.
Product Name:
PCDH1 Rabbit Polyclonal Antibody
SKU:
CAB10234
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 60-220 of human PCDH1 (NP_002578.2).
Cell junction, Cell membrane, Single-pass type I membrane protein.
Calculated MW:
115kDa
Observed MW:
115kDa
This gene belongs to the protocadherin subfamily within the cadherin superfamily. The encoded protein is a membrane protein found at cell-cell boundaries. It is involved in neural cell adhesion, suggesting a possible role in neuronal development. The protein includes an extracelllular region, containing 7 cadherin-like domains, a transmembrane region and a C-terminal cytoplasmic region. Cells expressing the protein showed cell aggregation activity. Alternative splicing occurs in this gene.
Purification Method:
Affinity purification
Gene ID:
5097
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PCDH1 antibody (CAB10234) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
