The PCBP4 Polyclonal Antibody (PACO28830) is a valuable tool for research involving PCBP4, a protein involved in RNA binding and regulation of gene expression. This rabbit-derived antibody has high specificity for human samples and is validated for use in Western blot applications. By binding to PCBP4, researchers can detect and analyze this important protein in a variety of cell types, making it a versatile tool for studies in molecular biology and cancer research.PCBP4, also known as poly(rC)-binding protein 4, plays a crucial role in post-transcriptional regulation of gene expression by binding to RNA molecules and influencing their stability and translation.
Its involvement in processes such as mRNA splicing and stability makes it a key player in cellular functions and disease processes. Research on PCBP4 can provide valuable insights into mechanisms underlying cancer development, RNA metabolism, and other biological pathways, paving the way for potential therapeutic interventions targeting PCBP4-related pathways.
Antibody Name:
PCBP4 Antibody (PACO28830)
Antibody SKU:
PACO28830
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Human
Immunogen:
Recombinant Human Poly(rC)-binding protein 4 protein (1-150AA)
Single-stranded nucleic acid, binding protein that binds preferentially to oligo dC.
Synonyms:
Poly(rC)-binding protein 4 (Alpha-CP4), PCBP4
UniProt Protein Function:
PCBP4: Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 3p21Cellular Component: cytoplasm; ribonucleoprotein complexMolecular Function: DNA binding; RNA binding
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple alternatively spliced transcript variants have been described, but the full-length nature for only some has been determined. [provided by RefSeq, Jul 2008]
