The PCBP4 Polyclonal Antibody (PACO11091) is a vital tool for researchers studying PCBP4, a multifunctional RNA-binding protein involved in gene regulation and mRNA stability. This antibody, produced in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to PCBP4, this antibody allows for precise detection and analysis of the protein in different cell types, making it an essential component of studies in molecular biology and cancer research.PCBP4, also known as poly(rC)-binding protein 4, plays a crucial role in post-transcriptional gene regulation by interacting with RNA molecules and influencing their stability and translation.
Its diverse functions in RNA metabolism make it a key player in processes like mRNA splicing, transport, and turnover. Researchers studying PCBP4 aim to elucidate its role in diseases such as cancer, neurodegenerative disorders, and viral infections, with the ultimate goal of developing targeted therapies based on these molecular insights. By using the PACO11091 antibody, scientists can delve deeper into the complex functions of PCBP4 and uncover new avenues for therapeutic intervention.
PCBP4: Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 3p21Cellular Component: cytoplasm; ribonucleoprotein complexMolecular Function: DNA binding; RNA binding
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple alternatively spliced transcript variants have been described, but the full-length nature for only some has been determined. [provided by RefSeq, Jul 2008]
