The PCBD1 Polyclonal Antibody (CAB6392) is a valuable tool for researchers studying PCBD1, a protein involved in the biosynthesis of neurotransmitters such as serotonin and dopamine. This antibody, raised in rabbits, is specifically designed for use in Western blot applications and is highly reactive with human samples.PCBD1, also known as pterin-4-alpha-carbinolamine dehydratase 1, plays a crucial role in the tetrahydrobiopterin (BH4) pathway, which is essential for the production of neurotransmitters and nitric oxide. Dysregulation of this pathway has been implicated in various neurological disorders, making PCBD1 a target of interest in neuroscience research.
By utilizing the PCBD1 Polyclonal Antibody, researchers can accurately detect and analyze PCBD1 expression in different cell types and tissues, providing valuable insights into its role in neurotransmitter synthesis and potential implications for neurological disorders. This antibody is a valuable tool for studies aiming to better understand the mechanisms underlying neurotransmitter regulation and identify new therapeutic targets for neurological conditions.
Product Name:
PCBD1 Rabbit Polyclonal Antibody
SKU:
CAB6392
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-104 of human PCBD1 (NP_000272.1).
This gene encodes a member of the pterin-4-alpha-carbinolamine dehydratase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein functions as both a dehydratase involved in tetrahydrobiopterin biosynthesis, and as a cofactor for HNF1A-dependent transcription. A deficiency of this enzyme leads to hyperphenylalaninemia. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
5092
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PCBD1 antibody (CAB6392) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
