Pyruvate carboxylase (PC) Rabbit Monoclonal Antibody (CAB8980)
- SKU:
- CAB8980
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
Product Name: | Pyruvate carboxylase (PC) Rabbit Monoclonal Antibody |
SKU: | CAB8980 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Pyruvate carboxylase (PC) (P11498). |
Sequence: | MLKF RTVH GGLR LLGI RRTS TAPA ASPN VRRL EYKP IKKV MVAN RGEI AIRV FRAC TELG IRTV AIYS EQDT GQMH RQKA DEAY LIGR GLAP VQAY LHIP |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | PCB; PC; Pyruvate carboxylase (PC) |
Positive Sample: | HepG2,Mouse liver,Mouse brain,Mouse kidney,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Mitochondrion matrix |
Calculated MW: | 130kDa |
Observed MW: | 130kDa |
This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 5091 |
Clone Number: | ARC1371 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |