The PBR Rabbit Monoclonal Antibody (CAB4881) is a powerful tool for researchers studying Peripheral Benzodiazepine Receptor (PBR) protein expression in various cell types. This antibody, produced in rabbits, is highly specific and suitable for use in Western blotting, immunofluorescence, and immunohistochemistry applications.The PBR protein, also known as Translocator Protein (TSPO), is involved in diverse cellular functions, including cholesterol transport, steroidogenesis, and immune response modulation. Its expression is often upregulated in conditions such as neuroinflammation, neurodegenerative diseases, and cancer, making it a potential biomarker and therapeutic target.
By using the PBR Rabbit Monoclonal Antibody (CAB4881), researchers can effectively detect and analyze PBR protein levels in their samples, enabling further investigation into the role of TSPO in various physiological and pathological processes. This antibody is a valuable tool for studies in neuroscience, immunology, and oncology, offering insight into the complexities of PBR signaling pathways and potential treatment options for associated diseases.
Product Name:
PBR/TSPO Rabbit Monoclonal Antibody
SKU:
CAB4881
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 70-169 of human PBR/TSPO (P30536).
Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein.
Purification Method:
Affinity purification
Gene ID:
706
Clone Number:
ARC0308
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using PBR/TSPO Rabbit mAb (CAB4881) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
