The Pax8 Polyclonal Antibody (CAB1009) is a valuable tool for researchers studying the transcription factor Pax8, which plays a crucial role in the development and function of thyroid, kidney, and other organs. This antibody, raised in rabbits, is highly specific for Pax8 and is validated for use in various applications including immunohistochemistry and immunofluorescence.Pax8 is known for its role in the regulation of thyroid-specific genes, making it an important target for studies related to thyroid development, function, and diseases such as thyroid cancer. The Pax8 Polyclonal Antibody enables researchers to detect and analyze Pax8 expression in tissue samples, providing valuable insights into its localization and function.
With its high specificity and sensitivity, the Pax8 Polyclonal Antibody is an essential tool for researchers interested in understanding the molecular mechanisms underlying organ development and function, as well as exploring potential therapeutic strategies for Pax8-related diseases. Whether studying thyroid biology or investigating the role of Pax8 in other tissues, this antibody is a valuable asset for advancing research in the field of developmental biology and endocrinology.
Product Name:
PAX8 Rabbit Polyclonal Antibody
SKU:
CAB1009
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human PAX8 (NP_003457.1).
This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described.
Purification Method:
Affinity purification
Gene ID:
7849
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PAX8 antibody (CAB1009) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
