PAX6 Rabbit Polyclonal Antibody (CAB7334)
- SKU:
- CAB7334
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Description
Product Name: | PAX6 Rabbit Polyclonal Antibody |
SKU: | CAB7334 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human PAX6 (NP_000271.1). |
Sequence: | MQNS HSGV NQLG GVFV NGRP LPDS TRQK IVEL AHSG ARPC DISR ILQV SNGC VSKI LGRY YETG SIRP RAIG GSKP RVAT PEVV SKIA QYKR ECPS IFAW EIRD RLLS EGVC TNDN IPSV SSIN RVLR NLAS EKQQ MGAD GMYD KLRM LNGQ TGSW GTRP GWYP GTSV PGQP TQDG CQQQ EGGG ENTN SISS NGED SDEA QMRL QLKR KLQR NRTS FTQE QIEA LEKE FERT HYPD VFAR ERLA AKID LPEA RIQV WFSN RRAK WRRE EKLR NQRR QASN TPSH IPIS SSFS TSVY QPIP |
Tested Applications: | WB IF/ICC IP ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-600μg extracts of whole cells |
Synonyms: | AN; AN1; AN2; FVH1; MGDA; WAGR; ASGD5; D11S812E; PAX6 |
Positive Sample: | Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 47kDa |
Observed MW: | 47kDa |
This gene encodes paired box protein Pax-6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to a conserved paired box domain, a hallmark feature of this gene family, the encoded protein also contains a homeobox domain. Both domains are known to bind DNA and function as regulators of gene transcription. Activity of this protein is key in the development of neural tissues, particularly the eye. This gene is regulated by multiple enhancers located up to hundreds of kilobases distant from this locus. Mutations in this gene or in the enhancer regions can cause ocular disorders such as aniridia and Peter's anomaly. Use of alternate promoters and alternative splicing results in multiple transcript variants encoding different isoforms. Interestingly, inclusion of a particular alternate coding exon has been shown to increase the length of the paired box domain and alter its DNA binding specificity. Consequently, isoforms that carry the shorter paired box domain regulate a different set of genes compared to the isoforms carrying the longer paired box domain.
Purification Method: | Affinity purification |
Gene ID: | 5080 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |