The PAX2 Polyclonal Antibody (CAB3067) is a valuable tool for researchers studying the PAX2 protein, which plays a crucial role in kidney development and various cancers. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the PAX2 protein, this antibody enables accurate detection and analysis in different cell types, making it an essential asset for studies in developmental biology and oncology research.
PAX2 is known for its involvement in the formation of the kidney, where it regulates the expression of genes essential for proper organ development. Additionally, aberrant expression of PAX2 has been implicated in various cancers, highlighting its potential as a therapeutic target for anti-cancer strategies. Understanding the role of PAX2 in both normal and diseased states is crucial for developing targeted therapies that can effectively modulate its activity for therapeutic benefit.
Product Name:
PAX2 Rabbit Polyclonal Antibody
SKU:
CAB3067
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 150-320 of human PAX2 (NP_003978.3).
PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor suppressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
5076
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PAX2 antibody (CAB3067) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
