The Pax1 Polyclonal Antibody (CAB17513) is a valuable tool for researchers studying the Pax1 protein, which is crucial for proper embryonic development, particularly in the formation of spinal structures. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for Western blot applications.Pax1 is a transcription factor that plays a key role in the regulation of genes involved in skeletal development, making it a critical factor in understanding conditions such as skeletal dysplasia and congenital vertebral defects.
By targeting Pax1 with this antibody, researchers can effectively detect and analyze the protein in a variety of cell types, providing valuable insights into its function.The significance of Pax1 in embryonic development and skeletal formation makes it a promising target for further study in developmental biology and musculoskeletal disorders. The Pax1 Polyclonal Antibody offers a reliable tool for investigating the role of Pax1 in these processes, paving the way for potential therapeutic interventions in related conditions.
Product Name:
PAX1 Rabbit Polyclonal Antibody
SKU:
CAB17513
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 300-400 of human PAX1 (NP_006183.2).
This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. This gene plays a role in pattern formation during embryogenesis and may be essential for development of the vertebral column. This gene is silenced by methylation in ovarian and cervical cancers and may be a tumor suppressor gene. Mutations in this gene are also associated with vertebral malformations.
Purification Method:
Affinity purification
Gene ID:
5075
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and 293T cells transfected with PAX1 using PAX1 Rabbit pAb (CAB17513) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
