PAR4 Rabbit Polyclonal Antibody (CAB3063)
- SKU:
- CAB3063
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Frequently bought together:
Description
Product Name: | PAR4 Rabbit Polyclonal Antibody |
SKU: | CAB3063 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human PAR4 (NP_002574.2) |
Sequence: | QNEA VNLL DPGS SYLL QEPP RTVS GRYK STTS VSEE DVSS RYSR TDRS GFPR YNRD ANVS GTLV SSST LEKK IEDL EKEV VRER QENL RLVR LMQD KEEM I |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | PAR4; Par-4 |
Positive Sample: | BT-474,HT-29,SKOV3,SW480,HepG2 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 37kDa |
Observed MW: | 43kDa |
This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases.
Purification Method: | Affinity purification |
Gene ID: | 5074 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |