PATZ1 Rabbit Polyclonal Antibody (CAB10053)
- SKU:
- CAB10053
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | PATZ1 Rabbit Polyclonal Antibody |
SKU: | CAB10053 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 250-350 of human PATZ1 (NP_055138.2). |
Sequence: | PFPS VASS APPL TGKR GRGR PRKA NLLD SMFG SPGG LREA GILP CGLC GKVF TDAN RLRQ HEAQ HGVT SLQL GYID LPPP RLGE NGLP ISED PDGP RKRS R |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:1000 - 1:5000 |
Synonyms: | ZSG; MAZR; PATZ; RIAZ; ZBTB19; ZNF278; dJ400N23; PATZ1 |
Positive Sample: | HeLa,A-549,Mouse kidney,Rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 74kDa |
Observed MW: | 74kDa |
The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene.
Purification Method: | Affinity purification |
Gene ID: | 23598 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |