The PATZ1 Polyclonal Antibody (CAB10053) is a key tool for researchers studying the PATZ1 protein, a transcription factor involved in the regulation of gene expression and cell cycle progression. This antibody, produced in rabbits, has high specificity for human samples and has been validated for use in Western blot applications.PATZ1, also known as MAZR, is known to play a role in various cellular processes, including cell proliferation, differentiation, and apoptosis. Its dysregulation has been associated with the development of cancer and other diseases, making it a target of interest in cancer research and beyond.
By using the PATZ1 Polyclonal Antibody, researchers can confidently detect and analyze the PATZ1 protein in different cell types, providing valuable insights into its function and potential therapeutic implications. This antibody is a valuable tool for studies in molecular biology, cancer biology, and developmental biology, aiding in the understanding of the complex roles of PATZ1 in cellular processes.
Product Name:
PATZ1 Rabbit Polyclonal Antibody
SKU:
CAB10053
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 250-350 of human PATZ1 (NP_055138.2).
The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene.
Purification Method:
Affinity purification
Gene ID:
23598
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using PATZ1 antibody (CAB10053) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
