The PARS2 Polyclonal Antibody (CAB16513) is a valuable tool for researchers studying the PARS2 protein, a mitochondrial enzyme essential for protein synthesis and function. Raised in rabbits, this antibody is highly specific and reacts with human samples, making it suitable for various applications such as Western blot and immunohistochemistry.PARS2, also known as prolyl-tRNA synthetase 2, plays a vital role in the translation of proline tRNA into prolyl-tRNA, a key step in protein synthesis. Dysfunction of PARS2 has been implicated in mitochondrial disorders and neurodegenerative diseases, making it an important target for further investigation.
With its high specificity and reactivity, the PARS2 Polyclonal Antibody enables precise detection and analysis of PARS2 protein levels in different cell types and tissues. Researchers in the fields of molecular biology, genetics, and neuroscience will find this antibody invaluable for their studies on mitochondrial function and disease mechanisms.
Product Name:
PARS2 Rabbit Polyclonal Antibody
SKU:
CAB16513
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 30-220 of human PARS2 (NP_689481.2).
This gene encodes a putative member of the class II family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of proline to tRNA molecules. Mutations have been found in this gene in some patients with Alpers syndrome.
Purification Method:
Affinity purification
Gene ID:
25973
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from rat brain, using PARS2 Rabbit pAb (CAB16513) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
