The PARP3 Polyclonal Antibody (CAB7297) is a valuable tool for researchers studying PARP3, a DNA repair enzyme involved in maintaining genomic stability and regulating cellular processes. This antibody, produced in rabbits, is highly specific to human samples and has been rigorously validated for use in Western blot applications. By binding to the PARP3 protein, this antibody enables precise detection and analysis in a variety of cell types, making it a crucial asset for studies in molecular biology, cancer research, and DNA repair mechanisms.
PARP3, also known as poly (ADP-ribose) polymerase 3, is instrumental in repairing DNA damage and promoting cell survival in response to genotoxic stress. Dysregulation of PARP3 has been linked to various diseases, including cancer and neurodegenerative disorders, making it an attractive target for therapeutic interventions. Investigating the functions of PARP3 with the help of this antibody can provide valuable insights into disease mechanisms and aid in the development of novel treatment strategies.
Product Name:
PARP3 Rabbit Polyclonal Antibody
SKU:
CAB7297
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 178-533 of human PARP3 (NP_005476.4).
The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified.
Purification Method:
Affinity purification
Gene ID:
10039
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat liver, using PARP3 Rabbit pAb (CAB7297) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
