The PARP15 Polyclonal Antibody (PACO11075) is specifically designed for research involving PARP15, a member of the poly (ADP-ribose) polymerase (PARP) family involved in DNA damage repair and cell survival pathways. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.PARP15 is known for its role in regulating DNA repair mechanisms and promoting cell survival under stress conditions. Its involvement in cellular processes such as DNA damage response and apoptosis makes it a key player in cancer research and therapeutic development.
By targeting PARP15, researchers can gain insight into the molecular mechanisms underlying cancer progression and potentially identify new targets for treatment.Furthermore, understanding the function of PARP15 may provide valuable information for developing personalized therapies and improving the efficacy of existing cancer treatments. This antibody offers a reliable tool for investigating the role of PARP15 in various cellular processes, making it a valuable asset for studies in oncology and DNA repair mechanisms.
poly (ADP-ribose) polymerase family, member 15;PARP15;BAL3;FLJ40196;FLJ40597;MGC126750;MGC126752 ;
UniProt Protein Function:
PARP15: Transcriptional repressor. Has ADP-ribosyltransferase activity. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 2.4.2.30; TransferaseChromosomal Location of Human Ortholog: 3q21.1Cellular Component: nucleusMolecular Function: NAD+ ADP-ribosyltransferase activity; protein bindingBiological Process: negative regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent
UniProt Protein Details:
NCBI Summary:
PARP15 is a macrodomain-containing transcriptional repressor with poly(ADP-ribose) polymerase activity (Aguiar et al., 2005 [PubMed 16061477]).[supplied by OMIM, May 2008]
