The PARP11 Polyclonal Antibody (PACO16842) is a valuable tool for researchers studying PARP11, a member of the poly(ADP-ribose) polymerase (PARP) family of enzymes involved in various cellular processes, including DNA repair and genome stability. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in Western blot applications. It recognizes the PARP11 protein, allowing for precise detection and analysis in a variety of cell types, making it a valuable asset for studies in molecular biology and cancer research.
PARP11 plays a crucial role in DNA damage response pathways and has been implicated in the development and progression of various cancers. Understanding the function and regulation of PARP11 is essential for advancing our knowledge of cancer biology and identifying potential therapeutic targets. With its high specificity and sensitivity, the PARP11 Polyclonal Antibody is an essential tool for researchers investigating the role of PARP11 in cancer and other disease states.
Antibody Name:
PARP11 Antibody (PACO16842)
Antibody SKU:
PACO16842
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human PARP11
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO16842(PARP11 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO16842(PARP11 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Poly(ADP-ribosylation) is a method of DNA damage-dependent posttranslational modification that helps to rescue injured proliferating cells from cell death. The PARP (poly(ADP-ribose) polymerase) proteins comprise a superfamily of enzymes that functionally modify histones and other nuclear proteins, thereby preventing cell death. PARPs use NAD+ as a substrate to catalytically transfer ADP-ribose residues onto protein acceptors; a process that, when repeated multiple times, leads to the formation of poly(ADPribose) chains on the protein.
