The PARP10 Polyclonal Antibody (CAB12815) is a valuable tool for researchers studying PARP10, a member of the poly (ADP-ribose) polymerase (PARP) family involved in DNA damage repair and regulation of gene expression. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the PARP10 protein, this antibody enables detection and analysis in a variety of cell types, making it suitable for studies in molecular biology, genetics, and cancer research.PARP10, also known as ARTD10, is a key player in maintaining genomic stability and DNA repair processes.
Dysregulation of PARP10 has been implicated in various diseases, including cancer and neurodegenerative disorders. Research on the functions and mechanisms of PARP10 can provide important insights into disease pathogenesis and potential therapeutic strategies targeting this enzyme.Overall, the PARP10 Polyclonal Antibody is a reliable tool for investigating the role of PARP10 in cellular processes and disease pathways, offering researchers valuable insights into the potential therapeutic implications of targeting this protein.
Product Name:
PARP10 Rabbit Polyclonal Antibody
SKU:
CAB12815
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human PARP10 (NP_116178.2).
Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005 [PubMed 15674325]).
Purification Method:
Affinity purification
Gene ID:
84875
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PARP10 Rabbit pAb (CAB12815) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
