The PARP1 Polyclonal Antibody (CAB11010) is a valuable tool for researchers studying the role of Poly(ADP-ribose) polymerase 1 (PARP1) in DNA repair and genomic stability. This antibody, produced in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blotting experiments. By binding specifically to the PARP1 protein, this antibody enables precise detection and analysis of PARP1 expression in various cellular systems.PARP1 is a critical enzyme involved in DNA repair processes, functioning to maintain genome integrity and prevent the accumulation of DNA damage. Dysregulation of PARP1 has been linked to various diseases, including cancer and neurological disorders.
By investigating the function and regulation of PARP1 using this antibody, researchers can gain insights into the mechanisms underlying disease pathogenesis and potentially identify novel therapeutic targets.Furthermore, understanding the role of PARP1 in DNA repair and cellular homeostasis is essential for the development of targeted therapies that exploit PARP1-related pathways in cancer treatment and personalized medicine. The PARP1 Polyclonal Antibody (CAB11010) provides a reliable tool for exploring the functions of PARP1 in physiological and pathological processes, offering new opportunities for advancing biomedical research and drug discovery efforts.
Product Name:
PARP1 Rabbit Polyclonal Antibody
SKU:
CAB11010
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human PARP1 (NP_001609.2).
This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
Purification Method:
Affinity purification
Gene ID:
142
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PARP1 antibody (CAB11010) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 20s.
