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PARN Rabbit Polyclonal Antibody (CAB6941)

SKU:
CAB6941
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
  • Epigenetics and Nuclear Signaling Antibodies 4 Anti-PARN Antibody CAB6941
  • Epigenetics and Nuclear Signaling Antibodies 4 Anti-PARN Antibody CAB6941
$167 - $503
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:PARN Rabbit Polyclonal Antibody
SKU:CAB6941
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human PARN (NP_002573.1).
Sequence:MEII RSNF KSNL HKVY QAIE EADF FAID GEFS GISD GPSV SALT NGFD TPEE RYQK LKKH SMDF LLFQ FGLC TFKY DYTD SKYI TKSF NFYV FPKP FNRS SPDV KFVC QSSS IDFL ASQG FDFN KVFR NGIP YLNQ EEER QLRE QYDE KRSQ ANGA GALS YVSP NTSK CPVT IPED QKKF IDQV VEKI EDLL QSEE NKNL DLEP CTGF QRKL IYQT LSWK YPKG IHVE TLET EKKE RYIV ISKV DEEE RKRR EQQK HAKE QEEL NDAV GFSR VIHA IANS
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:2000 IF/ICC,1:50 - 1:100
Synonyms:DAN; DKCB6; PFBMFT4; PARN
Positive Sample:A-549,MCF7,HepG2,HeLa
Conjugate:Unconjugated
Cellular Localization:Cytoplasm, Nucleus, nucleolus.
Calculated MW:73kDa
Observed MW:73kDa

The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Purification Method:Affinity purification
Gene ID:5073
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of various cell lines, using PARN antibody (CAB6941) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 150s.

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