The PARN Polyclonal Antibody (CAB6941) is a powerful tool for researchers studying PARN, a key enzyme involved in RNA metabolism and regulation. This antibody, raised in rabbits, offers high sensitivity and specificity when detecting PARN in various experimental settings. Validated for use in Western blot applications, it provides researchers with a reliable method for analyzing PARN expression levels in different cell types.PARN is known for its role in mRNA degradation and processing, making it a crucial player in gene expression regulation. Dysregulation of PARN has been linked to various diseases, including cancer and neurological disorders, highlighting the importance of studying this enzyme in greater detail.
By targeting PARN with this polyclonal antibody, researchers can gain valuable insights into its functions and potential therapeutic implications in RNA-related diseases.In summary, the PARN Polyclonal Antibody (CAB6941) is a valuable tool for researchers investigating the role of PARN in RNA metabolism and disease pathogenesis. Its high reactivity and specificity make it an essential component of any study involving PARN, providing reliable and accurate results for further analysis and exploration.
Product Name:
PARN Rabbit Polyclonal Antibody
SKU:
CAB6941
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human PARN (NP_002573.1).
The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
5073
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PARN antibody (CAB6941) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 150s.
