The PARL Polyclonal Antibody (PACO16839) is a valuable tool for researchers studying the PARL protein, a key player in mitochondrial dynamics and cell survival. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in various applications, including Western blot.PARL, also known as presenilin-associated rhomboid-like protein, is involved in the regulation of mitochondrial integrity and apoptosis. Its role in maintaining mitochondrial function and protecting cells from stress-induced death makes it a promising target for investigating diseases related to mitochondrial dysfunction, such as neurodegenerative disorders and cancer.
By utilizing the PARL Polyclonal Antibody, researchers can easily detect and analyze PARL protein levels in different cell types, providing valuable insights into its function and potential therapeutic applications. This antibody is a valuable tool for advancing research in mitochondria biology and cell survival pathways.
Antibody Name:
PARL Antibody (PACO16839)
Antibody SKU:
PACO16839
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Fusion protein of human PARL
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16839(PARL Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO16839(PARL Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms.
Synonyms:
presenilin associated, rhomboid-like
UniProt Protein Function:
PSARL: a mitochondrial intramembrane protease that is associated with insulin resistance and type 2 diabetes. Induced in humans by caloric restriction. Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals. Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain. Induced in humans by caloric restriction. Interacts with PSEN1 and PSEN2. Binds OPA1. Two isoforms of the human protein are produced by alternative splicing.
Biological Process: membrane protein proteolysis; proteolysis
NCBI Summary:
This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
