The PARL Polyclonal Antibody (PAC016838) is a valuable tool for researchers studying the PARL protein, a key player in mitochondrial function and regulation. This antibody, produced in rabbits, is highly specific to human samples and is ideal for use in Western blot applications. It binds to the PARL protein, allowing for precise detection and analysis in a variety of cell types.PARL, also known as presenilin-associated rhomboid-like protein, is involved in multiple cellular processes, including mitochondrial quality control, apoptosis, and lipid metabolism. Dysregulation of PARL has been associated with various diseases, such as neurodegenerative disorders and metabolic syndromes.
Therefore, understanding the function and regulation of PARL is crucial for developing targeted therapies for these conditions.With its high specificity and reliability, the PARL Polyclonal Antibody is a valuable tool for researchers investigating the role of PARL in health and disease. Its applications in immunology, cell biology, and disease research make it an essential reagent for laboratories focused on mitochondrial biology and related fields.
Antibody Name:
PARL Antibody (PACO16838)
Antibody SKU:
PACO16838
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Fusion protein of human PARL
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16838(PARL Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO16838(PARL Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms.
Synonyms:
presenilin associated, rhomboid-like
UniProt Protein Function:
PSARL: a mitochondrial intramembrane protease that is associated with insulin resistance and type 2 diabetes. Induced in humans by caloric restriction. Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals. Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain. Induced in humans by caloric restriction. Interacts with PSEN1 and PSEN2. Binds OPA1. Two isoforms of the human protein are produced by alternative splicing.
Biological Process: membrane protein proteolysis; proteolysis
NCBI Summary:
This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
