The PARK2 Polyclonal Antibody (CAB11172) is a valuable tool for researchers studying the PARK2 gene, also known as parkin. This cell surface molecule is involved in various cellular processes, including mitophagy, a crucial mechanism for maintaining mitochondrial quality and function.Raised in rabbits, this antibody exhibits high reactivity with human samples and is specially validated for use in Western blot applications. By binding to the PARK2 protein, researchers can detect and analyze its expression in different cell types, making it ideal for studies in neurodegenerative diseases, particularly Parkinson's disease.
PARK2 plays a vital role in controlling the turnover of damaged mitochondria, highlighting its importance in maintaining cellular homeostasis and preventing neurodegeneration. Dysfunction of PARK2 has been associated with the pathogenesis of Parkinson's disease, making it a promising target for therapeutic interventions aimed at restoring mitochondrial health and neuronal survival. By understanding the mechanisms underlying PARK2 activity, researchers can uncover new insights into disease pathogenesis and develop targeted treatments for neurodegenerative disorders.
Product Name:
Parkin Rabbit Polyclonal Antibody
SKU:
CAB11172
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-387 of human Parkin (NP_004553.2).
The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.
Purification Method:
Affinity purification
Gene ID:
5071
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Parkin Rabbit pAb (CAB11172) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
