The Park2 Polyclonal Antibody (CAB0968) is a valuable tool for researchers studying Park2, a protein associated with Parkinson's disease. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the Park2 protein, this antibody allows for the detection and analysis of Park2 in various cell types, making it an essential component of studies focused on neurodegenerative diseases.
Park2, also known as Parkin, is involved in the regulation of mitochondrial quality control and has been linked to the development of Parkinson's disease. Understanding the role of Park2 in these processes is critical for developing potential therapies for this debilitating condition. By using the Park2 Polyclonal Antibody, researchers can further elucidate the functions of Park2 and potentially identify new targets for intervention in Parkinson's disease.
Product Name:
Parkin Rabbit Polyclonal Antibody
SKU:
CAB0968
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 81-280 of human Parkin (NP_004553.2).
The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.
Purification Method:
Affinity purification
Gene ID:
5071
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and 293F cells transfected with Parkin using Parkin Rabbit pAb(CAB0968) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
