The PARG Polyclonal Antibody (CAB10577) is a highly specific research tool for studying poly(ADP-ribose) glycohydrolase (PARG), an enzyme involved in DNA repair and cell survival processes. This antibody, produced in rabbits, is optimized for use in Western blot experiments and is known for its high affinity to human samples.PARG is a key player in the regulation of DNA damage response and is essential for maintaining genomic stability. Dysregulation of PARG activity has been implicated in various diseases, including cancer and neurodegenerative disorders. By targeting PARG with this antibody, researchers can investigate the role of PARG in DNA repair pathways and explore its potential as a therapeutic target in disease treatment.
With its superior specificity and reactivity, the PARG Polyclonal Antibody (CAB10577) is an essential tool for scientists conducting research in areas such as genomics, cancer biology, and drug development. Its ability to detect PARG protein expression in different cell types makes it a versatile choice for studies aiming to unravel the complexities of DNA repair mechanisms and their impact on human health.
Product Name:
PARG Rabbit Polyclonal Antibody
SKU:
CAB10577
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 777-976 of human PARG (NP_003622.2).
Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
8505
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of PC-3 cells, using PARG antibody (CAB10577) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
