The PARG Monoclonal Antibody (ASG-CTV-1A10) is a vital tool for researchers studying Poly(ADP-ribose) glycohydrolase (PARG), an enzyme involved in DNA repair and cell survival. This antibody, developed through mouse hybridoma technology, exhibits high specificity and sensitivity in detecting PARG in various biological samples. Validated for use in immunofluorescence and immunoprecipitation assays, it allows for accurate visualization and analysis of PARG expression and localization in cells.PARG plays a crucial role in maintaining genomic stability and preventing DNA damage by catalyzing the hydrolysis of poly(ADP-ribose) chains.
Dysregulation of PARG activity has been linked to various diseases, including cancer and neurological disorders, making it a promising target for drug development and therapeutic interventions. By studying the functions of PARG, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially identify novel treatment strategies.
Product Name:
PARG Monoclonal Antibody
SKU:
CAB24811
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant Protein corresponding to a sequence within amino acids 777-976 of human PARG(NP_003622.2).
Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
8505
Clone Number:
ARC63810
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from PC-3 cells, using PARG Rabbit mAb (CAB24811) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
