The PARD6A Polyclonal Antibody (CAB3064) is a powerful tool for researchers studying PARD6A, a key regulator of cell polarity and tight junction formation. This antibody, produced using rabbits as the host species, exhibits high specificity and sensitivity for human samples, making it ideal for a variety of research applications, including Western blot analysis.PARD6A is a vital component of the PAR (Partitioning-defective) complex, which plays a crucial role in establishing and maintaining cell polarity by regulating the localization of key proteins involved in cell-cell junctions.
Dysregulation of PARD6A has been implicated in a variety of diseases, including cancer and neurological disorders, making it a promising target for therapeutic interventions.By using the PARD6A Polyclonal Antibody, researchers can effectively detect and analyze PARD6A protein expression in various cell types, providing valuable insights into its function and role in disease pathogenesis. This antibody's reliability and specificity make it an essential tool for advancing research in cell biology, cancer biology, and neuroscience.
Product Name:
PARD6A Rabbit Polyclonal Antibody
SKU:
CAB3064
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PARD6A (Q9NPB6).
This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Purification Method:
Affinity purification
Gene ID:
50855
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PARD6A Rabbit pAb (CAB3064) at 1:200 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
