The PAOX Polyclonal Antibody (PAC037582) is a valuable tool for researchers investigating the function of the PAOX protein. PAOX, also known as polyamine oxidase, is involved in the catabolism of polyamines, which play important roles in cell growth, differentiation, and apoptosis. This rabbit-derived antibody is highly specific to human samples and has been validated for use in Western blot applications.By binding to the PAOX protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for studies in metabolism, cancer research, and other fields where polyamines and their metabolizing enzymes are of interest.
The role of PAOX in regulating polyamine levels and cellular processes provides a promising avenue for exploring potential therapeutic strategies in diseases such as cancer and metabolic disorders.Researchers seeking to deepen their understanding of polyamine metabolism and its implications for human health will find the PAOX Polyclonal Antibody to be a valuable asset in their experimental toolkit.
Antibody Name:
Paox Antibody (PACO37582)
Antibody SKU:
PACO37582
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Mouse
Immunogen:
Recombinant Mouse Peroxisomal N(1)-acetyl-spermine/spermidine oxidase protein (1-504AA)
Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs.
Synonyms:
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase (EC 1.5.3.13) (Polyamine oxidase), Paox, Pao
UniProt Protein Function:
PAOX: Flavoenzyme which catalyzes the oxidation of N(1)- acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)- acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. Belongs to the flavin monoamine oxidase family. 11 isoforms of the human protein are produced by alternative splicing.Protein type: EC 1.5.3.13; OxidoreductaseChromosomal Location of Human Ortholog: 7|7 F4Cellular Component: cytoplasm; peroxisomal matrix; peroxisomeMolecular Function: oxidoreductase activity; polyamine oxidase activity; receptor bindingBiological Process: polyamine catabolic process; putrescine biosynthetic process; putrescine catabolic process; spermidine catabolic process; spermine catabolic process
