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PAOX Antibody (PACO11067)

SKU:
PACO11067
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$551

Description

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PAOX Antibody (PACO11067)

The PAOX Antibody (PACO11067) is a polyclonal antibody specifically designed for research involving PAOX, a protein involved in the oxidation of polyamines. This antibody, generated in rabbits, has high reactivity with human samples, making it ideal for use in Western blot applications. By binding to the PAOX protein, this antibody enables accurate detection and analysis in various cell types, making it a valuable tool for studies in biochemistry and cellular metabolism research.PAOX is a key player in the regulation of polyamine metabolism, a process crucial for cell growth and proliferation.

Dysregulation of PAOX activity has been implicated in various diseases, including cancer and metabolic disorders. Research into the functions of PAOX is essential for understanding its role in disease development and progression, and may lead to the identification of novel therapeutic targets for these conditions.Overall, the PACO11067 Antibody offers researchers a reliable tool for studying the functions of PAOX in various cellular pathways, opening up new avenues for exploring the potential therapeutic benefits of targeting PAOX in disease treatment strategies.

Antibody Name:PAOX Antibody (PACO11067)
Antibody SKU:PACO11067
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:
Species Reactivity:Human, Mouse, Rat
Immunogen:Human PAOX
Form:Liquid
Storage Buffer:PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:polyamine oxidase (exo-N4-amino);PAOX;DKFZp434J245;MGC45464;PAO ;
UniProt Protein Function:PAOX: Flavoenzyme which catalyzes the oxidation of N(1)- acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)- acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. Belongs to the flavin monoamine oxidase family. 11 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 1.5.3.13; Oxidoreductase

Chromosomal Location of Human Ortholog: 10q26.3

Cellular Component: peroxisomal matrix

Molecular Function:polyamine oxidase activity; receptor binding

Biological Process: spermine catabolic process; xenobiotic metabolic process; polyamine biosynthetic process; putrescine biosynthetic process; polyamine catabolic process; spermidine catabolic process; putrescine catabolic process; polyamine metabolic process

UniProt Code:Q6QHF9
NCBI GenInfo Identifier:51316248
NCBI Gene ID:196743
NCBI Accession:Q6QHF9.3
UniProt Secondary Accession:Q6QHF9,Q5VWY0, Q6QHF5, Q6QHF6, Q6QHF7, Q6QHF8, Q6QHG0 Q6QHG1, Q6QHG2, Q6QHG3, Q6QHG4, D3DXI6,
UniProt Related Accession:Q6QHF9
Molecular Weight:649
NCBI Full Name:Peroxisomal N(1)-acetyl-spermine/spermidine oxidase
NCBI Synonym Full Names:polyamine oxidase (exo-N4-amino)
NCBI Official Symbol:PAOX  
NCBI Official Synonym Symbols:PAO  
NCBI Protein Information:peroxisomal N(1)-acetyl-spermine/spermidine oxidase; peroxisomal N(1)-acetyl-spermine/spermidine oxidase; peroxisomal N1-acetyl-spermine/spermidine oxidase
UniProt Protein Name:Peroxisomal N(1)-acetyl-spermine/spermidine oxidase
UniProt Synonym Protein Names:Polyamine oxidase
Protein Family:Peroxisomal N(1)-acetyl-spermine/spermidine oxidase
UniProt Gene Name:PAOX  
UniProt Entry Name:PAOX_HUMAN

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