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PAOX Antibody (PACO01816)

SKU:
PACO01816
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269

Description

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PAOX Antibody (PACO01816)

The PAOX Polyclonal Antibody (PAC001816) is a valuable tool for researchers studying the PAOX protein, which plays a key role in oxidative stress response and lipid metabolism. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the PAOX protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential component for studies in fields such as biochemistry and cell biology.PAOX, also known as polyamine oxidase, is a critical enzyme involved in the breakdown of polyamines and the generation of reactive oxygen species.

Its role in regulating cellular oxidative stress makes it a potential target for research on various diseases, including cancer, neurodegenerative disorders, and metabolic conditions. Understanding the function of PAOX is essential for developing therapies that target oxidative stress pathways and metabolic dysregulation in these disease contexts.Overall, the PAOX Polyclonal Antibody offers researchers a powerful tool for investigating the function and regulation of the PAOX protein in various biological processes, leading to valuable insights and potential therapeutic advancements in related fields.

Antibody Name:PAOX Antibody
Antibody SKU:PACO01816
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:WB:1:500-1:2000
Species Reactivity:Human
Immunogen:synthesized peptide derived from the Internal region of human PAOX.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:PAOX; PAO; Peroxisomal N(1)-acetyl-spermine/spermidine oxidase; Polyamine oxidase
UniProt Protein Function:PAOX: Flavoenzyme which catalyzes the oxidation of N(1)- acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)- acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. Belongs to the flavin monoamine oxidase family. 11 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 1.5.3.13; Oxidoreductase

Chromosomal Location of Human Ortholog: 10q26.3

Cellular Component: peroxisomal matrix

Molecular Function:polyamine oxidase activity; receptor binding

Biological Process: spermine catabolic process; xenobiotic metabolic process; polyamine biosynthetic process; putrescine biosynthetic process; polyamine catabolic process; spermidine catabolic process; putrescine catabolic process; polyamine metabolic process

UniProt Code:Q6QHF9
NCBI GenInfo Identifier:51316248
NCBI Gene ID:196743
NCBI Accession:Q6QHF9.3
UniProt Secondary Accession:Q6QHF9,Q5VWY0, Q6QHF5, Q6QHF6, Q6QHF7, Q6QHF8, Q6QHG0 Q6QHG1, Q6QHG2, Q6QHG3, Q6QHG4, D3DXI6,
UniProt Related Accession:Q6QHF9
Molecular Weight:649
NCBI Full Name:Peroxisomal N(1)-acetyl-spermine/spermidine oxidase
NCBI Synonym Full Names:polyamine oxidase (exo-N4-amino)
NCBI Official Symbol:PAOX  
NCBI Official Synonym Symbols:PAO  
NCBI Protein Information:peroxisomal N(1)-acetyl-spermine/spermidine oxidase; peroxisomal N(1)-acetyl-spermine/spermidine oxidase; peroxisomal N1-acetyl-spermine/spermidine oxidase
UniProt Protein Name:Peroxisomal N(1)-acetyl-spermine/spermidine oxidase
UniProt Synonym Protein Names:Polyamine oxidase
Protein Family:Peroxisomal N(1)-acetyl-spermine/spermidine oxidase
UniProt Gene Name:PAOX  
UniProt Entry Name:PAOX_HUMAN

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