The Pannexin-1 Polyclonal Antibody (CAB6683) is a key tool for researchers studying pannexin-1, a protein involved in cell communication and signaling. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to pannexin-1, this antibody allows for the detection and analysis of this important protein in a variety of cell types, making it an invaluable resource for studies in cell biology and neuroscience.Pannexin-1 is known to play a crucial role in mediating various cellular functions, including the release of ATP and other signaling molecules.
Its involvement in processes such as inflammation, apoptosis, and synaptic plasticity makes pannexin-1 a target of interest in research on neurological disorders, immune responses, and more. By understanding the function and regulation of pannexin-1, researchers can gain valuable insights into the mechanisms underlying these complex biological processes and potentially develop new therapeutic strategies.
Product Name:
Pannexin 1 Rabbit Polyclonal Antibody
SKU:
CAB6683
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human Pannexin 1 (NP_056183.2).
The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties.
Purification Method:
Affinity purification
Gene ID:
24145
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Pannexin 1 antibody (CAB6683) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
