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PANK1 Antibody (PACO11064)

SKU:
PACO11064
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€459

Description

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PANK1 Antibody (PACO11064)

The PANK1 Polyclonal Antibody (PACO11064) is a valuable tool for researchers studying the PANK1 protein, which is involved in the biosynthesis of CoA (coenzyme A). CoA is essential for various metabolic processes in the cell, including fatty acid synthesis and the citric acid cycle. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.PANK1 is a key enzyme in the CoA biosynthesis pathway and plays a crucial role in maintaining cellular energy production and lipid metabolism. Dysregulation of PANK1 has been implicated in metabolic disorders such as obesity and diabetes, making it a promising target for therapeutic interventions.

By targeting the PANK1 protein, researchers can gain insights into metabolic pathways and potentially develop novel treatments for metabolic diseases.Overall, the PANK1 Polyclonal Antibody is a reliable tool for investigating the function and regulation of the PANK1 protein in various cellular contexts. Its specificity and sensitivity make it an excellent choice for studies in metabolic research, providing valuable information for understanding the role of PANK1 in health and disease.

Antibody Name:PANK1 Antibody (PACO11064)
Antibody SKU:PACO11064
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:
Species Reactivity:Human, Mouse, Rat
Immunogen:Human PANK1
Form:Liquid
Storage Buffer:PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity Purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:pantothenate kinase 1;PANK1;MGC24596;PANK;PANK1a;PANK1b ;
UniProt Protein Function:PANK1: Plays a role in the physiological regulation of the intracellular CoA concentration. Belongs to the type II pantothenate kinase family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; EC 2.7.1.33; Kinase, other

Chromosomal Location of Human Ortholog: 10q23.31

Cellular Component: recycling endosome; clathrin coat; nucleus; cytosol

Molecular Function:pantothenate kinase activity; ATP binding

Biological Process: coenzyme biosynthetic process; coenzyme A biosynthetic process; vitamin metabolic process; pantothenate metabolic process; phosphorylation; water-soluble vitamin metabolic process

NCBI Summary:This gene encodes a member of the pantothenate kinase family. Pantothenate kinases are key regulatory enzymes in the biosynthesis of coenzyme A (CoA). The encoded protein catalyzes the first and rate-limiting enzymatic reaction in CoA biosynthesis and is regulated by CoA through feedback inhibition. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene and an intronic miRNA on the same strand are co-regulated by the tumor suppressor p53 (see PMID 20833636). [provided by RefSeq, Apr 2011]
UniProt Code:Q8TE04
NCBI GenInfo Identifier:27805665
NCBI Gene ID:53354
NCBI Accession:Q8TE04.2
UniProt Secondary Accession:Q8TE04,Q7RTX6, Q7Z495, Q8TBQ8, A6NIP0,
UniProt Related Accession:Q8TE04
Molecular Weight:598
NCBI Full Name:Pantothenate kinase 1
NCBI Synonym Full Names:pantothenate kinase 1
NCBI Official Symbol:PANK1  
NCBI Official Synonym Symbols:PANK  
NCBI Protein Information:pantothenate kinase 1; pantothenic acid kinase 1
UniProt Protein Name:Pantothenate kinase 1
UniProt Synonym Protein Names:Pantothenic acid kinase 1
Protein Family:Pantothenate kinase
UniProt Gene Name:PANK1  
UniProt Entry Name:PANK1_HUMAN

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