Pan Cadherin Rabbit Monoclonal Antibody (CAB4903)
- SKU:
- CAB4903
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- Arc-1
- CD324
- CDHE
- ECAD
- LCAM
- UVO
Description
Product Name: | Pan Cadherin Rabbit Monoclonal Antibody |
SKU: | CAB4903 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 806-906 of human Cadherin-2 (CDH2) (P19022). |
Sequence: | IRRM DERP IHAE PQYP VRSA APHP GDIG DFIN EGLK AADN DPTA PPYD SLLV FDYE GSGS TAGS LSSL NSSS SGGE QDYD YLND WGPR FKKL ADMY GGGD D |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | Arc-1; CD324; CDHE; ECAD; LCAM; UVO; Pan Cadherin |
Positive Sample: | HeLa,Mouse liver |
Conjugate: | Unconjugated |
Cellular Localization: | actin cytoskeleton, adherens junction, apical junction complex, cell junction, cytoplasm, cytoplasmic side of plasma membrane, endosome, extracellular exosome, extracellular region, flotillin complex, glutamatergic synapse, lateral plasma membrane, perinuclear region of cytoplasm, plasma membrane, trans-Golgi network |
Calculated MW: | 140kDa |
Observed MW: | 140kDa |
This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]
Purification Method: | Affinity purification |
Gene ID: | 999/1000/1001/1001/1002/12561 |
Clone Number: | ARC1135 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |