The Palb2 Polyclonal Antibody (CAB8373) is a valuable tool for researchers studying the PALB2 gene, which is involved in DNA repair and maintenance of genomic stability. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in a variety of applications, including Western blotting.PALB2, a tumor suppressor gene, plays a crucial role in the repair of DNA double-strand breaks and in maintaining chromosomal integrity. Mutations in PALB2 have been linked to an increased risk of breast and ovarian cancer, making it an important target for cancer research.
By targeting PALB2 with this antibody, researchers can gain valuable insights into the molecular mechanisms underlying cancer development and potentially identify new therapeutic strategies for combating these diseases.Overall, the Palb2 Polyclonal Antibody (CAB8373) is a reliable tool for investigating the functions and implications of the PALB2 gene in cancer biology, DNA repair, and genomic stability. Its specificity and sensitivity make it an ideal choice for researchers looking to elucidate the role of PALB2 in health and disease.
Product Name:
PALB2 Rabbit Polyclonal Antibody
SKU:
CAB8373
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 99-198 of human PALB2 (NP_078951.2).
This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2.
Purification Method:
Affinity purification
Gene ID:
79728
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PALB2 antibody (CAB8373) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
