The Pak6 Polyclonal Antibody (CAB7821) is a valuable tool for researchers studying Pak6, a serine/threonine protein kinase that plays a key role in cellular processes such as cell proliferation, survival, and migration. This antibody, generated in rabbits, is highly specific to human samples and is validated for use in Western blot applications. By binding specifically to the Pak6 protein, this antibody allows for the accurate detection and analysis of Pak6 in various cell types, making it an essential component for studies in cell biology and cancer research.
Pak6, a member of the p21-activated kinase (PAK) family, is known to be dysregulated in various cancers and has been implicated in promoting tumor growth and metastasis. Understanding the function and regulation of Pak6 is essential for developing targeted therapies for cancer and other diseases where Pak6 plays a role. The Pak6 Polyclonal Antibody provides researchers with a reliable tool for investigating the role of Pak6 in disease pathogenesis and identifying potential therapeutic targets for intervention.
Product Name:
PAK6 Rabbit Polyclonal Antibody
SKU:
CAB7821
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human PAK6 (NP_064553.1).
This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
56924
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using PAK6 Rabbit pAb (CAB7821) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
