The Pak4 Polyclonal Antibody (CAB11646) is a valuable tool for researchers studying the Pak4 protein, a member of the p21-activated kinase (PAK) family involved in cell migration and invasion. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to Pak4, this antibody allows for precise detection and analysis in various cell types, making it an ideal choice for studies in cancer research and cell signaling pathways.
Pak4 is known for its role in promoting cell survival, proliferation, and motility, making it a key player in cancer progression and metastasis. Research into Pak4 has shown its potential as a therapeutic target for cancer treatment, making the Pak4 Polyclonal Antibody a valuable tool for further exploring its functions and mechanisms in cancer biology. Understanding the regulation and activity of Pak4 is essential for developing targeted therapies that can inhibit its oncogenic properties and improve patient outcomes.
Product Name:
PAK4 Rabbit Polyclonal Antibody
SKU:
CAB11646
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 450-550 of human PAK4 (NP_005875.1).
PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
10298
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from LNCaP cells, using PAK4 Rabbit pAb (CAB11646) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
