The Pak3 Polyclonal Antibody (CAB16942) is a valuable tool for researchers studying the Pak3 protein, a key regulator of cell migration and cytoskeletal organization. This antibody, generated in rabbits, exhibits high specificity and sensitivity in detecting Pak3 in human samples through Western blotting techniques. By targeting Pak3, researchers can investigate its role in various cellular processes, including cell adhesion, proliferation, and motility.Pak3, a member of the p21-activated kinase family, is involved in signaling pathways that control cytoskeletal dynamics and cellular morphology.
Dysregulation of Pak3 has been linked to numerous diseases, such as cancer, neurological disorders, and developmental abnormalities. Therefore, the Pak3 Polyclonal Antibody serves as a valuable resource for elucidating the functions and dysfunctions of Pak3 in biological systems, offering insights into potential therapeutic strategies for related conditions.
Product Name:
PAK3 Rabbit Polyclonal Antibody
SKU:
CAB16942
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PAK3 (NP_001121638.1).
cytoplasm, cytosol, endosome, glutamatergic synapse, plasma membrane, postsynaptic density
Calculated MW:
62kDa
Observed MW:
80kDa
The protein encoded by this gene is a serine-threonine kinase and forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of a non-syndromic form of X-linked intellectual disability. Alternatively spliced transcript variants encoding different isoforms have been identified.
Purification Method:
Affinity purification
Gene ID:
5063
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PAK3 Rabbit pAb (CAB16942) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
