The Pak2 Polyclonal Antibody (CAB7333) is a vital tool for research involving Pak2, a protein kinase involved in cell signaling pathways regulating cell morphology, motility, and proliferation. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards Pak2 in human samples, making it suitable for Western blot applications. By binding to Pak2, it enables precise detection and analysis in different cell types, making it an essential asset for studies in cell biology and cancer research.Pak2, a member of the p21-activated kinase (Pak) family, plays a crucial role in diverse cellular processes such as cytoskeletal dynamics, cell adhesion, and cell cycle progression.
Dysregulation of Pak2 has been implicated in various human diseases, including cancer and neurological disorders, emphasizing its importance as a potential therapeutic target. By understanding the functions and regulatory mechanisms of Pak2, researchers can develop novel strategies for treating diseases associated with Pak2 dysregulation.
Product Name:
PAK2 Rabbit Polyclonal Antibody
SKU:
CAB7333
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 120-240 of human PAK2 (NP_002568.2).
The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.
Purification Method:
Affinity purification
Gene ID:
5062
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PAK2 antibody (CAB7333) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
