The PAK1 Rabbit Monoclonal Antibody (CAB19608) is a valuable tool for researchers studying PAK1, a protein involved in cell signaling and regulation of cell structure. This antibody, generated from rabbit cells, exhibits high reactivity towards human samples and has been validated for use in Western blot applications. By specifically binding to the PAK1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for studies in cancer biology, cell biology, and signal transduction pathways.PAK1, a member of the p21-activated kinase (PAK) family, plays a crucial role in regulating cell growth, division, and movement.
Dysregulation of PAK1 has been linked to various diseases, including cancer, making it a promising target for therapeutic development. Understanding the function and activity of PAK1 is essential for unraveling its role in disease progression and exploring new treatment strategies.Overall, the PAK1 Rabbit Monoclonal Antibody (CAB19608) provides researchers with a reliable tool to investigate the biological functions of PAK1 and its potential implications in disease pathogenesis.
Product Name:
PAK1 Rabbit Monoclonal Antibody
SKU:
CAB19608
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PAK1 (Q13153).
This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Mutations in this gene have been associated with macrocephaly, seizures, and speech delay. Overexpression of this gene is also reported in many cancer types, and particularly in breast cancer. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
5058
Clone Number:
ARC0087
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using PAK1 Rabbit mAb (CAB19608) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
