PAK1 Rabbit Monoclonal Antibody (CAB19608)
- SKU:
- CAB19608
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Frequently bought together:
Description
Product Name: | PAK1 Rabbit Monoclonal Antibody |
SKU: | CAB19608 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PAK1 (Q13153). |
Sequence: | MSNN GLDI QDKP PAPP MRNT STMI GAGS KDAG TLNH GSKP LPPN PEEK KKKD RFYR SILP GDKT NKKK EKER PEIS LPSD FEHT IHVG FDAV TGEF TGMP |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | IDDMSSD; p65-PAK; PAKalpha; alpha-PAK; PAK1 |
Positive Sample: | HeLa,Jurkat,Mouse testis,Rat brain,C6 |
Conjugate: | Unconjugated |
Cellular Localization: | Cell junction, Cell membrane, Cell projection, Cytoplasm, focal adhesion, invadopodium, ruffle membrane. |
Calculated MW: | 61kDa |
Observed MW: | 65kDa |
This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Mutations in this gene have been associated with macrocephaly, seizures, and speech delay. Overexpression of this gene is also reported in many cancer types, and particularly in breast cancer. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 5058 |
Clone Number: | ARC0087 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |