The Pak1 Polyclonal Antibody (CAB3279) is a valuable tool for researchers studying Pak1, a key regulator of cell processes such as cell adhesion, migration, and proliferation. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blotting applications. By specifically targeting the Pak1 protein, this antibody enables the detection and analysis of Pak1 in various cell types, making it suitable for research in cell biology, cancer, and developmental biology.
Pak1, a member of the p21-activated kinase (PAK) family, is involved in numerous cellular pathways that contribute to cell survival and proliferation. Dysregulation of Pak1 has been implicated in cancer progression, making it a promising target for therapeutic interventions. By understanding the role of Pak1 in cellular signaling, researchers can gain insights into potential treatment strategies for cancer and other diseases associated with Pak1 dysfunction.
Product Name:
PAK1 Rabbit Polyclonal Antibody
SKU:
CAB3279
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human PAK1 (Q13153).
This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Mutations in this gene have been associated with macrocephaly, seizures, and speech delay. Overexpression of this gene is also reported in many cancer types, and particularly in breast cancer. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
5058
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse kidney, using PAK1 Rabbit pAb (CAB3279) at 1:700 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
