PAIP2 Antibody (PACO40234)
- SKU:
- PACO40234
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
PAIP2 Antibody (PACO40234)
The PAIP2 Polyclonal Antibody (PAC040234) is a valuable tool for researchers studying the PAIP2 protein, a key regulator of mRNA translation in eukaryotic cells. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for use in Western blot applications.PAIP2 is involved in the control of protein synthesis by interacting with factors that regulate mRNA translation initiation. Dysregulation of PAIP2 expression or activity has been linked to various diseases, including cancer and neurological disorders.
Therefore, research into the function of PAIP2 is essential for understanding its role in disease pathogenesis and identifying potential therapeutic targets.By using the PAIP2 Polyclonal Antibody, researchers can detect and analyze PAIP2 expression in different cell types, providing valuable insights into its function in cellular processes such as protein synthesis and gene expression. This antibody is a reliable tool for studies in molecular biology, cancer research, and other fields where understanding mRNA translation is crucial.
| Antibody Name: | PAIP2 Antibody (PACO40234) |
| Antibody SKU: | PACO40234 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Polyadenylate-binding protein-interacting protein 2 protein (1-127AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Hela whole cell lysate, Jurkat whole cell lysate, SH-SY5Y whole cell lysate, HEK293 whole cell lysate, Mouse lung tissue, Mouse liver tissue, Mouse kidney tissue, Mouse brain tissue. All lanes: PAIP2 antibody at 3.5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 15 kDa. Observed band size: 15 kDa. |
 | Immunofluorescent analysis of Hela cells using PACO40234 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human lung tissue using PACO40234 at dilution of 1:100. |
| Background: | Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization. |
| Synonyms: | Polyadenylate-binding protein-interacting protein 2 (PABP-interacting protein 2) (PAIP-2) (Poly(A)-binding protein-interacting protein 2), PAIP2, PAIP2A |
| UniProt Protein Function: | PAIP2: Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization. Interacts with the second and third RRM domains and C- terminus regions of PABPC1 in a 2:1 stoichiometry. Belongs to the PAIP2 family. |
| UniProt Protein Details: | Protein type:RNA-binding Chromosomal Location of Human Ortholog: 5q31.2 Cellular Component: cytoplasm Molecular Function:protein binding; translation repressor activity Biological Process: negative regulation of translational initiation |
| UniProt Code: | Q9BPZ3 |
| NCBI GenInfo Identifier: | 46397013 |
| NCBI Gene ID: | 51247 |
| NCBI Accession: | Q9BPZ3.1 |
| UniProt Secondary Accession: | Q9BPZ3,Q49A06, Q9H0Y5, Q9P0Q8, B2RBI1, D3DQC6, |
| UniProt Related Accession: | Q9BPZ3 |
| Molecular Weight: | 14,984 Da |
| NCBI Full Name: | Polyadenylate-binding protein-interacting protein 2 |
| NCBI Synonym Full Names: | poly(A) binding protein interacting protein 2 |
| NCBI Official Symbol: | PAIP2Â Â |
| NCBI Official Synonym Symbols: | PAIP-2; PAIP2AÂ Â |
| NCBI Protein Information: | polyadenylate-binding protein-interacting protein 2 |
| UniProt Protein Name: | Polyadenylate-binding protein-interacting protein 2 |
| Protein Family: | Polyadenylate-binding protein-interacting protein |
| UniProt Gene Name: | PAIP2Â Â |
| UniProt Entry Name: | PAIP2_HUMAN |
Related Products
PAIP2 Monoclonal Antibody [PAT1C12AT] (CPAB0460)
