The PAICS Polyclonal Antibody (CAB6450) is a valuable tool for researchers studying the PAICS protein, a key enzyme in the purine biosynthesis pathway. This antibody has been raised in rabbits and is highly reactive with human samples, making it ideal for use in Western blot applications.PAICS is essential for the de novo synthesis of purine nucleotides, which are crucial for DNA and RNA synthesis in proliferating cells. Dysregulation of the purine biosynthesis pathway, including PAICS, has been linked to various diseases such as cancer and immune disorders.
By detecting and analyzing PAICS expression in different cell types, researchers can gain insights into the role of this protein in disease development and progression.With its specificity and sensitivity, the PAICS Polyclonal Antibody is a valuable tool for furthering our understanding of purine metabolism and its implications in various pathological conditions. Whether you are studying cancer biology, immunology, or metabolic disorders, this antibody can help advance your research.
Product Name:
PAICS Rabbit Polyclonal Antibody
SKU:
CAB6450
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 176-425 of human PAICS (NP_001072992.1).
This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
10606
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PAICS antibody (CAB6450) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
