The PAI1 Rabbit Monoclonal Antibody (CAB19096) is a high-quality antibody designed for research involving PAI1, also known as Plasminogen Activator Inhibitor-1. PAI1 is a key regulator of the fibrinolytic system and plays a crucial role in controlling blood clot formation and degradation. This antibody, raised in rabbits, is highly specific and reactive with human samples, making it suitable for a wide range of research applications. It has been validated for use in Western blot and immunohistochemistry, allowing for the detection and analysis of PAI1 expression in various cell types and tissues.
PAI1 dysregulation has been implicated in a variety of diseases, including cardiovascular disorders, cancer, and metabolic syndrome. Understanding the role of PAI1 in these conditions is crucial for developing targeted therapies and diagnostic tools. The PAI1 Rabbit Monoclonal Antibody (CAB19096) provides a reliable tool for researchers studying PAI1 function and its involvement in disease progression.
Product Name:
PAI-1/Serpin E1 Rabbit Monoclonal Antibody
SKU:
CAB19096
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human PAI-1/Serpin E1 (P05121).
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. The protein also functions as a component of innate antiviral immunity. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia.
Purification Method:
Affinity purification
Gene ID:
5054
Clone Number:
ARC0473
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of HepG2 cells, using PAI-1/Serpin E1 antibody (CAB19096) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
